Glial cell line - derived neurotrophic factor ( gdnf ) was originally isolated based on its potent and specific ability to promote the survival and morphological differentiation of dopaminergic neurons and motoneurons in embryonic midbrain cultures . in addition , gdnf also support the survival and regulate the differentiation of many peripheral neurons , including sympathetic , parasympathetic , sensory and enteric neurons . gdnf also plays a crucial role outside the nervous system , as a morphogenetic factor in kidney development and as a regulator of spermatogonia differentiation Gfr 1與gdnf結(jié)合位點(diǎn)的研究膠質(zhì)細(xì)胞源性神經(jīng)營養(yǎng)因子( gdnf )對(duì)多巴胺能神經(jīng)元、運(yùn)動(dòng)神經(jīng)元、感覺神經(jīng)元、腸道神經(jīng)元等多種神經(jīng)元具有促進(jìn)存活及保護(hù)作用,它還能促進(jìn)腎臟的發(fā)育和精原細(xì)胞的成熟,因此,極有希望用于治療神經(jīng)損傷和神經(jīng)系統(tǒng)退行性病變。